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First NICE Guidance for B12 deficiency in over 16's

Consistent with a link between low selenium and the effects of the GPx1 polymorphisms, in regions endemic for Keshan disease, there was a significant difference in the distribution of alleles in cases and controls, with a greater risk for individuals with the Pro/Leu or Leu/Leu genotypes of developing Keshan disease [36]

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At baseline, the mean time since the first multiple sclerosis symptom was 16.8 years, and the mean time since conversion to secondary progressive multiple sclerosis was 3.8 years (SD 3.5)